Baking soda, a key ingredient in many baked foods, has now been found to fight the destructive inflammation of autoimmune diseases like rheumatoid arthritis. 

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The study was published in the latest issue of the Journal of Immunology.

Scientists at Augusta University say the over-the-counter antacid can encourage our spleen to promote an anti-inflammatory environment that could be therapeutic in the face of inflammatory disease.

According to the scientists, a study showed that when rats or healthy people drink a solution of baking soda, or sodium bicarbonate, it becomes a trigger for mesothelial cells sitting on the spleen to tell the fist-sized organ that there’s no need to mount a protective immune response.

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“We think the cholinergic signals that we know mediate this anti-inflammatory response aren’t coming directly from the vagal nerve innervating the spleen, but from the mesothelial cells that form these connections to the spleen,” said Paul O’Connor, a renal physiologist at Augusta University and the study’s author.

When they cut the vagal nerve, a big cranial nerve that starts in the brain and reaches into the heart, lungs and gut to help control things like a constant heart rate and food digestion.

It did not impact the mesothelial cells’ neuron-like behaviour.

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But when they removed or even just moved the spleen, it broke the fragile mesothelial connections and the anti-inflammatory response was lost, O’Connor said.

“You are not really turning anything off or on, you are just pushing it toward one side by giving an anti-inflammatory stimulus,” he said.

“It’s potentially a really safe way to treat inflammatory disease.”

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